منابع مشابه
Dermal Absorption of Chlorpyrifos
Geer et al. (2004) provided an interesting comparison between passive dosimetry measures and biomonitoring for chlorpyrifos (CP) exposure in pesticide workers. However, they made a questionable assumption of a 3% dermal absorption factor (DAF) for CP, stating: ‘[The] study by Nolan et al. (1984), supports the use of a 3% DAF, the Environmental Protection Agency (EPA) accepted value, whereas Kri...
متن کاملDermal absorption of a dilute aqueous solution of malathion
Malathion is an organophosphate pesticide commonly used on field crops, fruit trees, livestock, agriculture, and for mosquito and medfly control. Aerial applications can result in solubilized malathion in swimming pools and other recreational waters that may come into contact with human skin. To evaluate the human skin absorption of malathion for the assessment of risk associated with human exp...
متن کاملA physiologically based pharmacokinetic model of organophosphate dermal absorption.
The rate and extent of dermal absorption are important in the analysis of risk from dermal exposure to toxic chemicals and for the development of topically applied drugs, barriers, insect repellents, and cosmetics. In vitro flow-through cells offer a convenient method for the study of dermal absorption that is relevant to the initial processes of dermal absorption. This study describes a physio...
متن کاملAbsorption, pharmacokinetics, and safety of triclosan after dermal administration.
We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 ...
متن کاملOral and dermal absorption of chlorpyrifos: a human volunteer study.
OBJECTIVES To determine the kinetics of elimination of urinary dialkylphosphate metabolites after oral and dermally applied doses of the organophosphate pesticide chlorpyrifos to human volunteers and to determine whether these doses affected plasma and erythrocyte cholinesterase activity. METHOD Five volunteers ingested 1 mg (2852 nmol) of chlorpyrifos. Blood samples were taken over 24 hours ...
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ژورنال
عنوان ژورنال: Journal of Exposure Science & Environmental Epidemiology
سال: 2010
ISSN: 1559-0631,1559-064X
DOI: 10.1038/jes.2010.22